UniProt Q61091
Frizzled-8 (Q61091)
Frizzled-8 (UniProt Q61091): 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q61091
- Protein
- Frizzled-8
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 2 records with a druggable one
Structures
12 records of Q61091 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IJY | Crystal structure of the cysteine-rich domain of mouse frizzled 8 (MFZ8) | x-ray diffraction | A, B | — | — |
| 1IJY | Crystal structure of the cysteine-rich domain of mouse frizzled 8 (MFZ8) | x-ray diffraction | A, B | — | — |
| 4F0A | Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 | x-ray diffraction | A | — | — |
| 4F0A | Crystal structure of XWNT8 in complex with the cysteine-rich domain of frizzled 8 | x-ray diffraction | A | — | — |
| 6AHY | Wnt signaling complex | x-ray diffraction | A, C, E | NAG, PAM | 7 (best 0.45) |
| 6AHY | Wnt signaling complex | x-ray diffraction | A, C, E | NAG, PAM | — |
| 6TFB | Carbamazepine binds Frizzled8 | x-ray diffraction | A, B | N6W | 4 (best 0.43) |
| 6TFB | Carbamazepine binds FRIZZLED8 | x-ray diffraction | A, B | N6W | — |
| 6TFM | Frizzled8 CRD | x-ray diffraction | A, D, B, C | — | 8 (best 0.77) |
| 6TFM | FRIZZLED8 crd | x-ray diffraction | A, D, B, C | — | — |
| 8CTG | Extracellular architecture of an engineered canonical Wnt signaling ternary complex | electron microscopy | A | PAM | 1 (best 0.74) |
| Q61091 | AlphaFold monomer V2.0 prediction for frizzled-8 (Q61091) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4F0A chain A against the predicted model Q61091: TM-score 0.97, RMSD 0.80 Å
- 4F0A chain A against the predicted model Q61091: TM-score 0.97, RMSD 0.80 Å
- 6AHY chain E against the predicted model Q61091: TM-score 0.97, RMSD 0.73 Å
- 6AHY chain E against the predicted model Q61091: TM-score 0.97, RMSD 0.73 Å
- 1IJY chain B against the predicted model Q61091: TM-score 0.97, RMSD 0.88 Å
- 1IJY chain B against the predicted model Q61091: TM-score 0.97, RMSD 0.88 Å
- 1IJY chain A against the predicted model Q61091: TM-score 0.97, RMSD 0.95 Å
- 1IJY chain A against the predicted model Q61091: TM-score 0.97, RMSD 0.95 Å
- 6AHY chain A against the predicted model Q61091: TM-score 0.96, RMSD 0.85 Å
- 6AHY chain A against the predicted model Q61091: TM-score 0.96, RMSD 0.85 Å
Elsewhere
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