MolNFT v1 · #164912 · protein
Tubulin-inhibitor complex
6TDE: “Tubulin-inhibitor complex”. X-ray diffraction, 5 ligands (GTP, GDP, N3Z). MolNFT v1 #164912 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TDE
- Type
- protein
- Length
- 1,858 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P63043
- Ligands
- GTP, GDP, N3Z, MG, SO4
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 434 | — | — |
| B | — | protein | 430 | — | — |
| D | — | protein | 429 | — | — |
| E | — | protein | 131 | — | P63043 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B, C, D
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, D
- N3Z · ~{N}-[(10~{S})-3,4,5-trimethoxy-16-methylidene-14-oxatetracyclo[9.7.0.0^{2,7}.0^{13,17}]octadeca-1(18), 2,4,6,11,13(17)-hexaen-10-yl]ethanamide · ligand · 2 copies · chains A, B, C, D
- MG · Magnesium ion · metal · 2 copies · chains A, C, D
- SO4 · Sulfate ion · ion · 9 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6TDE · Tubulin-inhibitor complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63043
- Elsewhere: RCSB PDB 6TDE · PDBe 6TDE · UniProt P63043
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