MolNFT v1 · #164812 · protein

Oprm-mexa complex from the mexab-oprm pseudomonas aeruginosa whole assembly reconstituted in nanodiscs

6TA5 · Outer membrane protein oprm: “Oprm-mexa complex from the mexab-oprm pseudomonas aeruginosa whole assembly reconstituted in nanodiscs”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #164812 on GenesisL1: 3D…

PDB: 6TA5
Type: protein
Length: 6,519 residues
Chains: 12
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Outer membrane protein oprm; Mexa family multidrug efflux rnd transporter periplasmic…
UniProt: Q51487, A0A2V3GTR8, A0A069Q9M6
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 4 distinct chains · 39% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Outer membrane protein oprm	protein	455	60% helix, 11% strand	Q51487
D, F, H	Mexa family multidrug efflux rnd transporter periplasmic adaptor subunit	protein	345	19% helix, 34% strand	A0A2V3GTR8
E, G, I	Mexa family multidrug efflux rnd transporter periplasmic adaptor subunit	protein	343	18% helix, 34% strand	A0A2V3GTR8
J, K, L	Efflux pump membrane transporter	protein	1030	42% helix, 18% strand	A0A069Q9M6

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	871	0.88	0.90	84	empty
2	650	0.87	0.92	73	empty
3	463	0.86	0.93	74	empty
4	509	0.84	0.90	71	empty
5	1061	0.83	0.84	112	empty

Interfaces

33 interfaces between chains.

J–L · 3556 Å² buried · 31 hydrogen bonds · protein-protein
K–L · 3416 Å² buried · 35 hydrogen bonds · protein-protein
J–K · 3182 Å² buried · 25 hydrogen bonds · protein-protein
B–C · 2689 Å² buried · 34 hydrogen bonds · protein-protein
A–B · 2666 Å² buried · 36 hydrogen bonds · protein-protein

Compared structures

6TA5 · OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q51487
Every structure of UniProt A0A2V3GTR8
Every structure of UniProt A0A069Q9M6
Elsewhere: RCSB PDB 6TA5 · PDBe 6TA5 · UniProt Q51487 · UniProt A0A2V3GTR8 · UniProt A0A069Q9M6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.