Research workbench
Oprm-mexa complex from the mexab-oprm pseudomonas aeruginosa whole assembly reconstituted in nanodiscs
Analyse Oprm-mexa complex from the mexab-oprm pseudomonas aeruginosa whole assembly… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TA5
- Type
- protein
- Length
- 6,519 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Outer membrane protein oprm; Mexa family multidrug efflux rnd transporter periplasmic…
- UniProt
- Q51487, A0A2V3GTR8, A0A069Q9M6
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 4 distinct chains · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Outer membrane protein oprm | protein | 455 | 60% helix, 11% strand | Q51487 |
| D, F, H | Mexa family multidrug efflux rnd transporter periplasmic adaptor subunit | protein | 345 | 19% helix, 34% strand | A0A2V3GTR8 |
| E, G, I | Mexa family multidrug efflux rnd transporter periplasmic adaptor subunit | protein | 343 | 18% helix, 34% strand | A0A2V3GTR8 |
| J, K, L | Efflux pump membrane transporter | protein | 1030 | 42% helix, 18% strand | A0A069Q9M6 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 871 | 0.88 | 0.90 | 84 | empty |
| 2 | 650 | 0.87 | 0.92 | 73 | empty |
| 3 | 463 | 0.86 | 0.93 | 74 | empty |
| 4 | 509 | 0.84 | 0.90 | 71 | empty |
| 5 | 1061 | 0.83 | 0.84 | 112 | empty |
Interfaces
33 interfaces between chains.
- J–L · 3556 Ų buried · 31 hydrogen bonds · protein-protein
- K–L · 3416 Ų buried · 35 hydrogen bonds · protein-protein
- J–K · 3182 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 2689 Ų buried · 34 hydrogen bonds · protein-protein
- A–B · 2666 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 6TA5 · OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q51487
- Every structure of UniProt A0A2V3GTR8
- Every structure of UniProt A0A069Q9M6
- Elsewhere: RCSB PDB 6TA5 · PDBe 6TA5 · UniProt Q51487 · UniProt A0A2V3GTR8 · UniProt A0A069Q9M6
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