MolNFT v1 · #164579 · protein + RNA
Bat influenza a polymerase recycling complex
6T2C · Polymerase acidic protein: “Bat influenza a polymerase recycling complex”. Electron microscopy, 1 ligand (MG), 20 pockets (best druggability 0.77). MolNFT v1 #164579 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6T2C
- Type
- protein + RNA
- Length
- 1,284 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase acidic protein; RNA-directed RNA polymerase catalytic subunit; Polymerase…
- EC
- 2.7.7.48
- UniProt
- H6QM92, H6QM91, H6QM90
- Ligands
- MG
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 4 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase acidic protein | protein | 513 | 39% helix, 19% strand | H6QM92 |
| B | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 626 | 41% helix, 16% strand | H6QM91 |
| C | Polymerase basic protein 2 | protein | 116 | 33% helix, 16% strand | H6QM90 |
| V | Vrna | rna | 29 | — | — |
Ligands and binding sites
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.77 | 0.97 | 26 | empty |
| 2 | 82 | 0.74 | 0.97 | 22 | empty |
| 3 | 999 | 0.73 | 0.77 | 82 | empty |
| 4 | 454 | 0.69 | 0.81 | 53 | empty |
| 5 | 72 | 0.69 | 0.94 | 19 | empty |
Interfaces
6 interfaces between chains.
- A–B · 8288 Ų buried · 94 hydrogen bonds · protein-protein
- B–C · 2871 Ų buried · 24 hydrogen bonds · protein-protein
- A–V · 2085 Ų buried · 39 hydrogen bonds · protein-nucleic
- B–V · 982 Ų buried · 14 hydrogen bonds · protein-nucleic
- A–C · 791 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6T2C · Bat Influenza A polymerase recycling complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H6QM92
- Every structure of UniProt H6QM91
- Every structure of UniProt H6QM90
- Elsewhere: RCSB PDB 6T2C · PDBe 6T2C · UniProt H6QM92 · UniProt H6QM91 · UniProt H6QM90
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