MolNFT v1 · #164531 · protein + RNA
Bat influenza a polymerase product dissociation complex using 44-mer vrna template with mutated OLIGO(U) sequence
6T0R · Polymerase acidic protein: “Bat influenza a polymerase product dissociation complex using 44-mer vrna template with mutated OLIGO(U)…”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #164531 on GenesisL1: 3D…
- PDB
- 6T0R
- Type
- protein + RNA
- Length
- 1,710 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase acidic protein; RNA-directed RNA polymerase catalytic subunit; Polymerase…
- EC
- 2.7.7.48
- UniProt
- H6QM92, H6QM91, H6QM90
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 4 distinct chains · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase acidic protein | protein | 701 | 42% helix, 17% strand | H6QM92 |
| B | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 739 | 43% helix, 15% strand | H6QM91 |
| C | Polymerase basic protein 2 | protein | 250 | 43% helix, 16% strand | H6QM90 |
| V | Vrna | rna | 20 | — | — |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 990 | 0.80 | 0.82 | 83 | empty |
| 2 | 395 | 0.77 | 0.86 | 59 | empty |
| 3 | 81 | 0.76 | 0.99 | 27 | empty |
| 4 | 1117 | 0.75 | 0.78 | 85 | empty |
| 5 | 798 | 0.75 | 0.79 | 68 | empty |
Interfaces
6 interfaces between chains.
- A–B · 9178 Ų buried · 133 hydrogen bonds · protein-protein
- B–C · 5990 Ų buried · 55 hydrogen bonds · protein-protein
- A–V · 2294 Ų buried · 45 hydrogen bonds · protein-nucleic
- B–V · 1522 Ų buried · 25 hydrogen bonds · protein-nucleic
- A–C · 1126 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6T0R · Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H6QM92
- Every structure of UniProt H6QM91
- Every structure of UniProt H6QM90
- Elsewhere: RCSB PDB 6T0R · PDBe 6T0R · UniProt H6QM92 · UniProt H6QM91 · UniProt H6QM90
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