MolNFT v1 · #164426 · protein

Crystal structure of the voltage-gated sodium channel navms in complex with 4-hydroxytamoxifen (2.4 ångström resolution)

6SXG · Ion transport protein: “Crystal structure of the voltage-gated sodium channel navms in complex with 4-hydroxytamoxifen (2.4 ångström…”. X-ray diffraction, 3 ligands (2CV, OHT, NA), 2 pockets (best druggability 0.50). MolNFT v1…

PDB: 6SXG
Type: protein
Length: 271 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ion transport protein
UniProt: A0L5S6
Ligands: 2CV, OHT, NA
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ion transport protein	protein	271	81% helix, 0% strand	A0L5S6

Ligands and binding sites

2CV · Hega-10 · ligand · 3 copies · chains A
OHT · 4-hydroxytamoxifen · ligand · 2 copies · chains A
NA · Sodium ion · metal · 3 copies · chains A
12P · Dodecaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.50	0.78	20	empty
2	53	0.37	0.80	9	empty

Compared structures

6SXG · Crystal Structure of the Voltage-Gated Sodium Channel NavMs in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0L5S6
Elsewhere: RCSB PDB 6SXG · PDBe 6SXG · UniProt A0L5S6

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