MolNFT v1 · #162954 · protein

Crystal structure of V57G mutant of human cystatin C

6ROA · Cystatin-C: “Crystal structure of V57G mutant of human cystatin C”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #162954 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6ROA
Type: protein
Length: 218 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cystatin-C
UniProt: P01034
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cystatin-C	protein	109	22% helix, 50% strand	P01034

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	119	0.61	0.86	23	empty
2	93	0.56	0.86	20	empty
3	55	0.26	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 1027 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6ROA · Crystal structure of V57G mutant of human cystatin C · the same entry in another collection · chain A against A, TM-score 1.00
P01034 · AlphaFold monomer V2.0 prediction for cystatin-C (P01034) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01034
Elsewhere: RCSB PDB 6ROA · PDBe 6ROA · UniProt P01034

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.