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Crystal structure of V57G mutant of human cystatin C
Analyse Crystal structure of V57G mutant of human cystatin C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ROA
- Type
- protein
- Length
- 218 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cystatin-C
- UniProt
- P01034
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 22% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cystatin-C | protein | 109 | 22% helix, 50% strand | P01034 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.61 | 0.86 | 23 | empty |
| 2 | 93 | 0.56 | 0.86 | 20 | empty |
| 3 | 55 | 0.26 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1027 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01034
- Elsewhere: RCSB PDB 6ROA · PDBe 6ROA · UniProt P01034
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