MolNFT v1 · #162395 · protein
Crystal structure of the central region of human cohesin subunit STAG1
6R7O · Cohesin subunit sa-1: “Crystal structure of the central region of human cohesin subunit STAG1”. X-ray diffraction, 10 pockets (best druggability 0.41). MolNFT v1 #162395 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6R7O
- Type
- protein
- Length
- 863 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cohesin subunit sa-1
- UniProt
- Q8WVM7
- Pockets
- 10 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cohesin subunit sa-1 | protein | 433 | 76% helix, 0% strand | Q8WVM7 |
| B | Cohesin subunit sa-1 | protein | 430 | 75% helix, 0% strand | Q8WVM7 |
Pockets
10 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.41 | 0.79 | 16 | empty |
| 2 | 59 | 0.37 | 0.79 | 15 | empty |
| 3 | 120 | 0.37 | 0.73 | 22 | empty |
| 4 | 97 | 0.35 | 0.74 | 16 | empty |
| 5 | 54 | 0.35 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 260 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6R7O · Crystal structure of the central region of human cohesin subunit STAG1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WVM7 · AlphaFold monomer V2.0 prediction for cohesin subunit sa-1 (Q8WVM7) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WVM7
- Elsewhere: RCSB PDB 6R7O · PDBe 6R7O · UniProt Q8WVM7
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