UniProt Q8WVM7
Cohesin subunit SA-1 (Q8WVM7)
Cohesin subunit SA-1 (UniProt Q8WVM7): 39 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 145 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WVM7
- Protein
- Cohesin subunit SA-1
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 145 · 6 records with a druggable one
Structures
40 records of Q8WVM7 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5QSM | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z57261895 | x-ray diffraction | A, B | O2D | 11 (best 0.42) |
| 5QSM | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z57261895 | x-ray diffraction | A, B | O2D | — |
| 5QSN | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z1272480091 | x-ray diffraction | A, B | O2J | 9 (best 0.47) |
| 5QSN | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z1272480091 | x-ray diffraction | A, B | O2J | — |
| 5QSO | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z466628048 | x-ray diffraction | A, B | O2M | 10 (best 0.45) |
| 5QSO | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z466628048 | x-ray diffraction | A, B | O2M | — |
| 5QSP | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434929 | x-ray diffraction | A, B | LVV | 11 (best 0.47) |
| 5QSP | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z2856434929 | x-ray diffraction | A, B | LVV | — |
| 5QSQ | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z396380540 | x-ray diffraction | A, B | HR5 | 10 (best 0.44) |
| 5QSQ | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z396380540 | x-ray diffraction | A, B | HR5 | — |
| 5QSR | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z136583524 | x-ray diffraction | A, B | NU4 | — |
| 5QSR | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z136583524 | x-ray diffraction | A, B | NU4 | — |
| 5QSS | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z33452282 | x-ray diffraction | A, B | O2P | 10 (best 0.43) |
| 5QSS | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z33452282 | x-ray diffraction | A, B | O2P | — |
| 5QST | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2447286438 | x-ray diffraction | C, A, B, D | O3A | — |
| 5QST | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z2447286438 | x-ray diffraction | C, A, B, D | O3A | — |
| 5QSU | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434926 | x-ray diffraction | C, A, B, D | O3D | 9 (best 0.63) |
| 5QSU | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z2856434926 | x-ray diffraction | C, A, B, D | O3D | — |
| 5QSV | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434783 | x-ray diffraction | C, A, B, D | O3G | — |
| 5QSV | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z2856434783 | x-ray diffraction | C, A, B, D | O3G | — |
| 5QSW | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434884 | x-ray diffraction | C, A, B, D | O3J | — |
| 5QSW | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z2856434884 | x-ray diffraction | C, A, B, D | O3J | — |
| 5QSX | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z2856434812 | x-ray diffraction | C, A, B, D | O3M | — |
| 5QSX | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z2856434812 | x-ray diffraction | C, A, B, D | O3M | — |
| 5QSY | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z755044716 | x-ray diffraction | A, B | K0J | 11 (best 0.45) |
| 5QSY | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z755044716 | x-ray diffraction | A, B | K0J | — |
| 5QSZ | PanDDA analysis group deposition -- Crystal Structure of human STAG1 in complex with Z1267773786 | x-ray diffraction | A, B | K3J | — |
| 5QSZ | Pandda analysis group deposition -- crystal structure of human STAG1 in complex with Z1267773786 | x-ray diffraction | A, B | K3J | — |
| 6QB5 | Crystal structure of the N-terminal region of human cohesin subunit STAG1 | x-ray diffraction | C, A, B, D | NA | 8 (best 0.64) |
| 6QB5 | Crystal structure of the N-terminal region of human cohesin subunit STAG1 | x-ray diffraction | C, A, B, D | NA | — |
| 6R7O | Crystal structure of the central region of human cohesin subunit STAG1 | x-ray diffraction | A, B | — | 10 (best 0.41) |
| 6R7O | Crystal structure of the central region of human cohesin subunit STAG1 | x-ray diffraction | A, B | — | — |
| 6RRC | Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21… | x-ray diffraction | C, A | SO4 | 7 (best 0.60) |
| 6RRC | Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21… | x-ray diffraction | C, A | SO4 | — |
| 6RRK | Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide | x-ray diffraction | B, A | — | 10 (best 0.47) |
| 6RRK | Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide | x-ray diffraction | B, A | — | — |
| 6WG3 | Cryo-EM structure of human Cohesin-NIPBL-DNA complex | electron microscopy | D | — | 5 (best 0.80) |
| 6WG3 | Cryo-EM structure of human cohesin-nipbl-DNA complex | electron microscopy | D | — | — |
| 7W1M | Cryo-EM structure of human cohesin-CTCF-DNA complex | electron microscopy | D | — | 4 (best 0.86) |
| Q8WVM7 | AlphaFold monomer V2.0 prediction for cohesin subunit sa-1 (Q8WVM7) | predicted | A | — | 20 (best 0.79) |
Ligands
- HR5 · ~{N}-(cyclobutylmethyl)-1,5-dimethyl-pyrazole-4-carboxamide · in 2 records
- K0J · N-ethyl-1H-1,2,3-triazole-4-carboxamide · in 2 records
- K3J · N-ethyl-6-methylpyridazin-3-amine · in 2 records
- LVV · 4-[(4-methylphenyl)methyl]-1,4-thiazinane 1,1-dioxide · in 2 records
- NA · Sodium ion · in 2 records
- NU4 · 2-methyl-N-(pyridin-4-yl)furan-3-carboxamide · in 2 records
- O2D · 2-cyclohexyl-N-(4H-1,2,4-triazol-4-yl)acetamide · in 2 records
- O2J · (2R)-2-(methoxymethyl)-4-(pyridin-2-yl)morpholine · in 2 records
- O2M · N-[(4-methyl-1,3-thiazol-2-yl)methyl]-1H-pyrazole-5-carboxamide · in 2 records
- O2P · N-(2-hydroxy-4-methylphenyl)-2-methylbenzamide · in 2 records
- O3A · (3S)-N-methyl-N-phenylpyrrolidine-3-carboxamide · in 2 records
- O3D · 4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione · in 2 records
- O3G · N-benzyl-1-(4-fluorophenyl)methanamine · in 2 records
- O3J · 1-[4-(3-phenylpropyl)piperazin-1-yl]ethan-1-one · in 2 records
- O3M · 4-[(3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenol · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6RRC chain A against the predicted model Q8WVM7: TM-score 0.97, RMSD 1.32 Å
- 6RRC chain A against the predicted model Q8WVM7: TM-score 0.97, RMSD 1.32 Å
- 6RRK chain B against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.64 Å
- 6RRK chain B against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.64 Å
- 5QSX chain D against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.39 Å
- 5QSX chain D against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.39 Å
- 5QST chain D against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.40 Å
- 5QST chain D against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.40 Å
- 5QSW chain D against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.41 Å
- 5QSW chain D against the predicted model Q8WVM7: TM-score 0.96, RMSD 1.41 Å
Elsewhere
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