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Crystal structure of the central region of human cohesin subunit STAG1

Analyse Crystal structure of the central region of human cohesin subunit STAG1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6R7O
Type: protein
Length: 863 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cohesin subunit sa-1
UniProt: Q8WVM7
Pockets: 10 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cohesin subunit sa-1	protein	433	76% helix, 0% strand	Q8WVM7
B	Cohesin subunit sa-1	protein	430	75% helix, 0% strand	Q8WVM7

Pockets

10 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	81	0.41	0.79	16	empty
2	59	0.37	0.79	15	empty
3	120	0.37	0.73	22	empty
4	97	0.35	0.74	16	empty
5	54	0.35	0.79	17	empty

Interfaces

1 interface between chains.

A–B · 260 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6R7O · Crystal structure of the central region of human cohesin subunit STAG1 · the same entry in another collection · chain A against A, TM-score 1.00
Q8WVM7 · AlphaFold monomer V2.0 prediction for cohesin subunit sa-1 (Q8WVM7) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WVM7
Elsewhere: RCSB PDB 6R7O · PDBe 6R7O · UniProt Q8WVM7

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