MolNFT v1 · #162348 · protein
Crystal structure of human TMEM16K / anoctamin 10 (form 2)
6R65 · Anoctamin-10: “Crystal structure of human TMEM16K / anoctamin 10 (form 2)”. X-ray diffraction, 1 ligand (CA), 20 pockets (best druggability 0.79). MolNFT v1 #162348 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6R65
- Type
- protein
- Length
- 1,234 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anoctamin-10
- UniProt
- Q9NW15
- Ligands
- CA
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anoctamin-10 | protein | 611 | 66% helix, 8% strand | Q9NW15 |
| B | Anoctamin-10 | protein | 623 | 65% helix, 8% strand | Q9NW15 |
Ligands and binding sites
- CA · Calcium ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 687 | 0.79 | 0.84 | 82 | empty |
| 2 | 965 | 0.77 | 0.79 | 71 | empty |
| 3 | 550 | 0.74 | 0.82 | 53 | empty |
| 4 | 731 | 0.71 | 0.78 | 46 | empty |
| 5 | 660 | 0.70 | 0.78 | 40 | empty |
Interfaces
1 interface between chains.
- A–B · 1564 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NW15
- Elsewhere: RCSB PDB 6R65 · PDBe 6R65 · UniProt Q9NW15
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