MolNFT v1 · #162296 · protein

Structure of a truncated adenylyl cyclase bound to mant-GTP, forskolin and an activated stimulatory galphas protein

6R4O: “Structure of a truncated adenylyl cyclase bound to mant-GTP, forskolin and an activated stimulatory galphas…”. Electron microscopy, 5 ligands (ONM, FOK, GSP). MolNFT v1 #162296 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 6R4O
Type: protein
Length: 1,182 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: E1BM79, P04896
Ligands: ONM, FOK, GSP, MN, MG

Structure

electron microscopy · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	841	—	E1BM79
B	—	protein	341	—	P04896

Ligands and binding sites

ONM · 3'-O-(N-methylanthraniloyl)-guanosine-5'-triphosphate · ligand · chains A
FOK · Forskolin · ligand · chains A
GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains B
MN · Manganese (II) ion · metal · 2 copies · chains A
MG · Magnesium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6R4O · Structure of a truncated adenylyl cyclase bound to MANT-GTP, forskolin and an activated… · the same entry in another collection · chain A against A, TM-score 1.00
P04896 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E1BM79
Every structure of UniProt P04896
Elsewhere: RCSB PDB 6R4O · PDBe 6R4O · UniProt E1BM79 · UniProt P04896

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