UniProt P04896
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (P04896)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (UniProt P04896): 57 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 30 pockets. Binding sites, druggability and experiment against…
- UniProt
- P04896
- Protein
- Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
- Experimental structures
- 57
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 30 · 4 records with a druggable one
Structures
58 records of P04896 in the MolNFT archive: 57 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AZS | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase | x-ray diffraction | C | — | — |
| 1AZS | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase | x-ray diffraction | C | — | — |
| 1AZT | Gs-alpha complexed with GTP-gamma-S | x-ray diffraction | A, B | — | — |
| 1AZT | Gs-alpha complexed with GTP-gamma-S | x-ray diffraction | A, B | — | — |
| 1CJK | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CJK | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CJT | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CJT | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CJU | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CJU | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CJV | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CJV | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CS4 | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CS4 | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CUL | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1CUL | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 1TL7 | Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With… | x-ray diffraction | C | — | — |
| 1TL7 | Complex of gs- with the catalytic domains of mammalian adenylyl cyclase: complex with 2'(3')-O-(N… | x-ray diffraction | C | — | — |
| 1U0H | Structural basis for the inhibition of mammalian adenylyl cyclase by mant-GTP | x-ray diffraction | C | — | — |
| 1U0H | Structural basis for the inhibition of mammalian adenylyl cyclase by mant-GTP | x-ray diffraction | C | — | — |
| 2GVD | Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With TNP-ATP and Mn | x-ray diffraction | C | — | — |
| 2GVD | Complex of gs- with the catalytic domains of mammalian adenylyl cyclase: complex with tnp-ATP and mn | x-ray diffraction | C | — | — |
| 2GVZ | Crystal Structure of Complex of Gs- with The Catalytic Domains of Mammalian Adenylyl Cyclase… | x-ray diffraction | C | — | — |
| 2GVZ | Crystal structure of complex of gs- with the catalytic domains of mammalian adenylyl cyclase… | x-ray diffraction | C | — | — |
| 3C14 | Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with… | x-ray diffraction | C | — | — |
| 3C14 | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 3C15 | Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with… | x-ray diffraction | C | — | — |
| 3C15 | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 3C16 | Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with… | x-ray diffraction | C | — | — |
| 3C16 | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 3G82 | Complex of GS-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with MANT-ITP… | x-ray diffraction | C | — | — |
| 3G82 | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with mant-itp… | x-ray diffraction | C | — | — |
| 3MAA | Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with… | x-ray diffraction | C | — | — |
| 3MAA | Complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with… | x-ray diffraction | C | — | — |
| 3SN6 | Crystal structure of the beta2 adrenergic receptor-Gs protein complex | x-ray diffraction | A | — | — |
| 3SN6 | Crystal structure of the BETA2 adrenergic receptor-gs protein complex | x-ray diffraction | A | — | — |
| 6R3Q | The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein | electron microscopy | B | GSP, MG | — |
| 6R4O | Structure of a truncated adenylyl cyclase bound to mant-GTP, forskolin and an activated stimulatory… | electron microscopy | B | GSP, MG | — |
| 6R4P | Structure of a soluble domain of adenylyl cyclase bound to an activated stimulatory G protein | electron microscopy | B | GSP, MG | — |
| 7DTY | Structural basis of ligand selectivity conferred by the human glucose- dependent insulinotropic… | electron microscopy | A | — | — |
| 7FIM | Cryo-EM structure of the tirzepatide (LY3298176)-bound human glp-1R-gs complex | electron microscopy | A | — | — |
| 7FIN | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human gipr-gs complex | electron microscopy | A | — | — |
| 7FIY | Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex | electron microscopy | A | — | — |
| 7FIY | Cryo-EM structure of the tirzepatide-bound human gipr-gs complex | electron microscopy | A | — | — |
| 7JJO | Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound… | electron microscopy | A | — | 10 (best 0.81) |
| 7JJO | Structural basis of the activation of heterotrimeric gs-protein by isoproterenol-bound… | electron microscopy | A | — | — |
| 7PDE | Structure of adenylyl cyclase 9 in complex with gs protein alpha subunit and mant-GTP | electron microscopy | B | GSP, MG | — |
| 7PDF | Focus refinement of soluble domain of adenylyl cyclase 9 in complex with gs protein alpha subunit… | electron microscopy | B | GSP, MG | — |
| 7S0G | Isoproterenol bound BETA1 adrenergic receptor in complex with heterotrimeric GI/S chimera protein | electron microscopy | A | — | — |
| 7VQX | Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with… | electron microscopy | A | — | — |
| 7WBJ | Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R)… | electron microscopy | A | — | — |
| 7WBJ | Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R)… | electron microscopy | A | — | — |
| 8BUZ | Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and… | electron microscopy | B | GSP, MG | 5 (best 0.79) |
| 8DCR | Cryo-EM structure of dobutamine-bound BETA1-adrenergic receptor in complex with heterotrimeric… | electron microscopy | A | — | — |
| 8DCS | Cryo-EM structure of cyanopindolol-bound BETA1-adrenergic receptor in complex with heterotrimeric… | electron microscopy | A | — | — |
| 8ITM | Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein | electron microscopy | A | — | 7 (best 0.85) |
| 9IJE | Epinephrine-activated human beta3 adrenergic receptor | electron microscopy | A | — | 8 (best 0.85) |
| P04896 | AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit alpha… | predicted | A | — | — |
Ligands
Experiment against prediction
- 1AZT chain A against the predicted model P04896: TM-score 0.99, RMSD 0.65 Å
- 1AZT chain A against the predicted model P04896: TM-score 0.99, RMSD 0.65 Å
- 2GVD chain C against the predicted model P04896: TM-score 0.99, RMSD 0.66 Å
- 2GVD chain C against the predicted model P04896: TM-score 0.99, RMSD 0.66 Å
- 3C16 chain C against the predicted model P04896: TM-score 0.99, RMSD 0.67 Å
- 3C16 chain C against the predicted model P04896: TM-score 0.99, RMSD 0.67 Å
- 3C14 chain C against the predicted model P04896: TM-score 0.99, RMSD 0.70 Å
- 3C14 chain C against the predicted model P04896: TM-score 0.99, RMSD 0.70 Å
- 6R4P chain B against the predicted model P04896: TM-score 0.99, RMSD 0.72 Å
- 1CUL chain C against the predicted model P04896: TM-score 0.99, RMSD 0.73 Å
Elsewhere
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