MolNFT v1 · #16220 · protein
D2 hexamerization domain of N-ethylmaleimide sensitive factor (nsf)
1NSF: “D2 hexamerization domain of N-ethylmaleimide sensitive factor (nsf)”. X-ray diffraction, 2 ligands (ATP, MG), 2 pockets (best druggability 0.63). MolNFT v1 #16220 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1NSF
- Type
- protein
- Length
- 247 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-ethylmaleimide sensitive factor
- UniProt
- P18708
- Ligands
- ATP, MG
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-ethylmaleimide sensitive factor | protein | 247 | 48% helix, 16% strand | P18708 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.63 | 0.82 | 30 | MG, ATP |
| 2 | 70 | 0.33 | 0.75 | 19 | empty |
Compared structures
- 1NSF · D2 hexamerization domain of N-ethylmaleimide sensitive factor (nsf) · the same entry in another collection · chain A against A, TM-score 1.00
- P18708 · AlphaFold monomer V2.0 prediction for vesicle-fusing ATPase (P18708) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18708
- Elsewhere: RCSB PDB 1NSF · PDBe 1NSF · UniProt P18708
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