MolNFT v1 · #270524 · protein
AlphaFold monomer V2.0 prediction for vesicle-fusing ATPase (P18708)
P18708: “AlphaFold monomer V2.0 prediction for vesicle-fusing ATPase (P18708)”. 9 pockets (best druggability 0.66). MolNFT v1 #270524 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P18708
- Type
- protein
- Length
- 744 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6DAA77C4263E74E745cA9c4D8E291e57e8991Cf5
- Molecule
- Vesicle-fusing ATPase
- UniProt
- P18708
- Pockets
- 9 · best druggability 0.66
Structure
1 distinct chain · 41% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vesicle-fusing ATPase | protein | 744 | 41% helix, 22% strand | P18708 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 299 | 0.66 | 0.82 | 36 | empty |
| 2 | 335 | 0.61 | 0.78 | 33 | empty |
| 3 | 268 | 0.57 | 0.77 | 48 | empty |
| 4 | 197 | 0.54 | 0.78 | 21 | empty |
| 5 | 208 | 0.49 | 0.76 | 28 | empty |
Compared structures
- 6MDM · The 20S supercomplex engaging the snap-25 N-terminus (class 1) · an experimental structure of the same protein · chain A against C, TM-score 0.87
- 3J99 · Structure of 20S supercomplex determined by single particle cryoelectron microscopy… · an experimental structure of the same protein · chain A against C, TM-score 0.85
- 3J99 · Structure of 20S supercomplex determined by single particle cryoelectron microscopy… · an experimental structure of the same protein · chain A against C, TM-score 0.85
- 6MDN · The 20S supercomplex engaging the SNAP-25 N-terminus (class 2) · an experimental structure of the same protein · chain A against B, TM-score 0.84
- 6MDN · The 20S supercomplex engaging the snap-25 N-terminus (class 2) · an experimental structure of the same protein · chain A against B, TM-score 0.84
- 3J97 · Structure of 20S supercomplex determined by single particle cryoelectron microscopy… · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 3J97 · Structure of 20S supercomplex determined by single particle cryoelectron microscopy… · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 3J96 · Structure of 20S supercomplex determined by single particle cryoelectron microscopy… · an experimental structure of the same protein · chain A against D, TM-score 0.82
- 3J96 · Structure of 20S supercomplex determined by single particle cryoelectron microscopy… · an experimental structure of the same protein · chain A against D, TM-score 0.82
- 3J98 · Structure of 20S supercomplex determined by single particle cryoelectron microscopy… · an experimental structure of the same protein · chain A against D, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18708
- Elsewhere: UniProt P18708 · AlphaFold DB P18708
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