MolNFT v1 · #161681 · protein
Idol F3AB subdomain
6QLZ · E3 ubiquitin-protein ligase mylip: “Idol F3AB subdomain”. X-ray diffraction, 5 pockets (best druggability 0.47). MolNFT v1 #161681 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6QLZ
- Type
- protein
- Length
- 285 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase mylip
- EC
- 2.3.2.27
- UniProt
- Q8WY64
- Pockets
- 5 · best druggability 0.47
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase mylip (EC 2.3.2.27) | protein | 98 | 16% helix, 46% strand | Q8WY64 |
| B | E3 ubiquitin-protein ligase mylip (EC 2.3.2.27) | protein | 91 | 20% helix, 49% strand | Q8WY64 |
| C | E3 ubiquitin-protein ligase mylip (EC 2.3.2.27) | protein | 96 | 18% helix, 52% strand | Q8WY64 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.47 | 0.76 | 30 | empty |
| 2 | 155 | 0.45 | 0.76 | 30 | empty |
| 3 | 89 | 0.41 | 0.77 | 19 | empty |
| 4 | 106 | 0.37 | 0.75 | 21 | empty |
| 5 | 54 | 0.25 | 0.72 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–B · 660 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 466 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WY64
- Elsewhere: RCSB PDB 6QLZ · PDBe 6QLZ · UniProt Q8WY64
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