UniProt Q8WY64
E3 ubiquitin-protein ligase MYLIP (Q8WY64)
E3 ubiquitin-protein ligase MYLIP (UniProt Q8WY64), EC 2.3.2.27: 7 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8WY64
- Protein
- E3 ubiquitin-protein ligase MYLIP
- EC
- 2.3.2.27
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 2 records with a druggable one
Structures
8 records of Q8WY64 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YHN | The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor | x-ray diffraction | A, B | — | — |
| 2YHN | The idol-UBE2D complex mediates sterol-dependent degradation of the LDL receptor | x-ray diffraction | A, B | — | — |
| 2YHO | The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor | x-ray diffraction | A, C, E, G | — | — |
| 2YHO | The idol-UBE2D complex mediates sterol-dependent degradation of the LDL receptor | x-ray diffraction | A, C, E, G | — | — |
| 6QLY | IDOL FERM domain | x-ray diffraction | A | SO4 | 1 (best 0.75) |
| 6QLY | Idol ferm domain | x-ray diffraction | A | SO4 | — |
| 6QLZ | Idol F3AB subdomain | x-ray diffraction | A, B, C | — | — |
| Q8WY64 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase mylip (Q8WY64) | predicted | A | — | 5 (best 0.69) |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6QLZ chain B against the predicted model Q8WY64: TM-score 0.97, RMSD 0.73 Å
- 2YHO chain A against the predicted model Q8WY64: TM-score 0.94, RMSD 0.86 Å
- 2YHO chain A against the predicted model Q8WY64: TM-score 0.94, RMSD 0.86 Å
- 2YHN chain A against the predicted model Q8WY64: TM-score 0.94, RMSD 0.71 Å
- 2YHN chain A against the predicted model Q8WY64: TM-score 0.94, RMSD 0.71 Å
- 6QLZ chain A against the predicted model Q8WY64: TM-score 0.93, RMSD 1.55 Å
- 6QLZ chain C against the predicted model Q8WY64: TM-score 0.93, RMSD 1.68 Å
- 2YHO chain E against the predicted model Q8WY64: TM-score 0.91, RMSD 1.11 Å
- 2YHO chain E against the predicted model Q8WY64: TM-score 0.91, RMSD 1.11 Å
- 6QLY chain A against the predicted model Q8WY64: TM-score 0.84, RMSD 1.54 Å
Elsewhere
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