MolNFT v1 · #255450 · protein
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase mylip (Q8WY64)
Q8WY64: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase mylip (Q8WY64)”. 5 pockets (best druggability 0.69). MolNFT v1 #255450 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8WY64
- Type
- protein
- Length
- 445 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x025f3b1a898b05AD2731bE6Ab72687b5920c4A3F
- Molecule
- E3 ubiquitin-protein ligase mylip
- UniProt
- Q8WY64
- Pockets
- 5 · best druggability 0.69
Structure
1 distinct chain · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase mylip | protein | 445 | 37% helix, 22% strand | Q8WY64 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 455 | 0.69 | 0.80 | 56 | empty |
| 2 | 98 | 0.57 | 0.86 | 22 | empty |
| 3 | 283 | 0.48 | 0.72 | 31 | empty |
| 4 | 120 | 0.41 | 0.75 | 27 | empty |
| 5 | 68 | 0.33 | 0.75 | 18 | empty |
Compared structures
- 6QLY · Idol ferm domain · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 6QLY · IDOL FERM domain · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 6QLZ · IDOL F3ab subdomain · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 6QLZ · Idol F3AB subdomain · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 2YHO · The idol-UBE2D complex mediates sterol-dependent degradation of the LDL receptor · an experimental structure of the same protein · chain A against E, TM-score 0.15
- 2YHO · The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor · an experimental structure of the same protein · chain A against E, TM-score 0.15
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WY64
- Elsewhere: UniProt Q8WY64 · AlphaFold DB Q8WY64
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