MolNFT v1 · #160908 · protein
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.
6PXW: “Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top…”. Electron microscopy, 20 pockets (best druggability 0.78). MolNFT v1 #160908 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6PXW
- Type
- protein
- Length
- 1,386 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P06213, A6XGL2
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 3 distinct chains · 18% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insulin receptor (EC 2.7.10.1) | protein | 601 | 13% helix, 27% strand | P06213 |
| C, D | Insulin | protein | 48 | 48% helix, 4% strand | A6XGL2 |
| E, F | Insulin | protein | 44 | 52% helix, 0% strand | A6XGL2 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 548 | 0.78 | 0.85 | 80 | empty |
| 2 | 673 | 0.67 | 0.76 | 60 | empty |
| 3 | 251 | 0.67 | 0.84 | 32 | empty |
| 4 | 578 | 0.64 | 0.76 | 68 | empty |
| 5 | 497 | 0.63 | 0.76 | 33 | empty |
Interfaces
9 interfaces between chains.
- A–B · 2470 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 848 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 842 Ų buried · 4 hydrogen bonds · protein-protein
- A–F · 756 Ų buried · 11 hydrogen bonds · protein-protein
- B–E · 741 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 40 disulfide (disulfide).
Compared structures
- 6PXW · Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was… · the same entry in another collection · chain C against C, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt A6XGL2
- Elsewhere: RCSB PDB 6PXW · PDBe 6PXW · UniProt P06213 · UniProt A6XGL2
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