MolNFT v1 · #160545 · protein
Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2- methoxyethyl)-N-METHYLSULFAMOYL)PHENYL)ACETAMIDE
6PNN · Glutathione S-transferase omega-1: “Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2- methoxyethyl)-N-METHYLSULFAMOYL)PHENYL)ACETAMIDE”. X-ray diffraction, 2 ligands (OR7, SO4), 3 pockets (best druggability 0.58). MolNFT v1…
- PDB
- 6PNN
- Type
- protein
- Length
- 238 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase omega-1
- EC
- 2.5.1.18, 1.8.5.1, 1.20.4.2
- UniProt
- P78417
- Ligands
- OR7, SO4
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutathione S-transferase omega-1 (EC 2.5.1.18, 1.8.5.1, 1.20.4.2) | protein | 238 | 53% helix, 9% strand | P78417 |
Ligands and binding sites
- OR7 · 2-chloro-N-{4-chloro-3-[(2-methoxyethyl)(methyl) sulfamoyl]phenyl}acetamide · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- TLA · L(+)-tartaric acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 253 | 0.58 | 0.78 | 32 | TLA, OR7 |
| 2 | 61 | 0.41 | 0.81 | 17 | empty |
| 3 | 77 | 0.30 | 0.73 | 16 | SO4 |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 6PNN · Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)… · the same entry in another collection · chain A against A, TM-score 1.00
- P78417 · AlphaFold monomer V2.0 prediction for glutathione S-transferase omega-1 (P78417) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78417
- Elsewhere: RCSB PDB 6PNN · PDBe 6PNN · UniProt P78417
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