UniProt P78417
Glutathione S-transferase omega-1 (P78417)
Glutathione S-transferase omega-1 (UniProt P78417), EC 1.20.4.2, 1.8.5.1: 30 experimental structures on GenesisL1, 11 ligands bound, 7 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P78417
- Protein
- Glutathione S-transferase omega-1
- EC
- 1.20.4.2, 1.8.5.1, 2.5.1.18
- Experimental structures
- 30
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 7 · 3 records with a druggable one
Structures
30 records of P78417 in the MolNFT archive: 30 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EEM | Glutathione transferase from homo sapiens | x-ray diffraction | A | — | — |
| 1EEM | Glutathione transferase from homo sapiens | x-ray diffraction | A | — | — |
| 3LFL | Crystal Structure of human Glutathione Transferase Omega 1, delta 155 | x-ray diffraction | A, B, C | — | — |
| 3LFL | Crystal structure of human glutathione transferase omega 1, delta 155 | x-ray diffraction | A, B, C | — | — |
| 3VLN | Human Glutathione Transferase O1-1 C32S Mutant in Complex with Ascorbic Acid | x-ray diffraction | A | — | — |
| 3VLN | Human glutathione transferase O1-1 C32S mutant in complex with ascorbic acid | x-ray diffraction | A | — | — |
| 4IS0 | Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and… | x-ray diffraction | A | — | — |
| 4IS0 | Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and… | x-ray diffraction | A | — | — |
| 4YQM | Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-27 | x-ray diffraction | A, B, C | — | — |
| 4YQM | Glutathione S-transferase omega 1 bound to covalent inhibitor C1-27 | x-ray diffraction | A, B, C | — | — |
| 4YQU | Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-31 | x-ray diffraction | A, B | — | — |
| 4YQU | Glutathione S-transferase omega 1 bound to covalent inhibitor C1-31 | x-ray diffraction | A, B | — | — |
| 4YQV | Glutathione S-transferase Omega 1 bound to covalent inhibitor C4-10 | x-ray diffraction | A, B, C | — | — |
| 4YQV | Glutathione S-transferase omega 1 bound to covalent inhibitor C4-10 | x-ray diffraction | A, B, C | — | — |
| 5UEH | Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate | x-ray diffraction | A | 85P, SO4 | — |
| 5V3Q | Human GSTO1-1 complexed with ML175 | x-ray diffraction | A | MLX, SO4 | 2 (best 0.59) |
| 5V3Q | Human GSTO1-1 complexed with ML175 | x-ray diffraction | A | MLX, SO4 | — |
| 5YVN | Human glutathione transferase OMEGA1 | x-ray diffraction | A | GSH, SO4 | — |
| 5YVO | Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor | x-ray diffraction | A | SO4, MLX | — |
| 5YVO | Human glutathione transferase OMEGA1 covalently bound to ML175 inhibitor | x-ray diffraction | A | SO4, MLX | — |
| 6MHB | Glutathione S-transferase omega 1 bound to covalent inhibitor 18 | x-ray diffraction | A, B, C, D, E, F | JR7 | — |
| 6MHC | Glutathione S-Transferase Omega 1 bound to covalent inhibitor 37 | x-ray diffraction | A, B | JRM | — |
| 6MHC | Glutathione S-transferase omega 1 bound to covalent inhibitor 37 | x-ray diffraction | A, B | JRM | — |
| 6MHD | Glutathione S-transferase omega 1 bound to covalent inhibitor 44 | x-ray diffraction | A, B | JRD, ACN | — |
| 6PNM | Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3- (MORPHOLINOSULFONYL)PHENYL)ACETAMIDE | x-ray diffraction | A | XX0, SO4 | — |
| 6PNN | Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)phenyl)ace… | x-ray diffraction | A | SO4, OR7 | 3 (best 0.58) |
| 6PNN | Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2… | x-ray diffraction | A | SO4, OR7 | — |
| 6PNO | Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-isopropylsulfamoyl)phenyl)acetamide | x-ray diffraction | A | ORM, SO4 | 2 (best 0.59) |
| 6PNO | Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N- ISOPROPYLSULFAMOYL)PHENYL)ACETAMIDE | x-ray diffraction | A | ORM, SO4 | — |
| P78417 | AlphaFold monomer V2.0 prediction for glutathione S-transferase omega-1 (P78417) | — | — | — |
Ligands
- SO4 · Sulfate ion · in 11 records
- MLX · N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide · in 4 records
- JRM · methyl N-(4-phenyl-1,3-thiazol-2-yl)-N-propanoylglycinate · in 2 records
- OR7 · 2-chloro-N-{4-chloro-3-[(2-methoxyethyl)(methyl) sulfamoyl]phenyl}acetamide · in 2 records
- ORM · 2-chloro-N-{4-chloro-3-[(propan-2-yl) sulfamoyl]phenyl}acetamide · in 2 records
- 85P · 2-(4-chlorophenyl)-6-[(fluorosulfonyl)oxy]quinoline-4-carboxylic acid · in 1 record
- ACN · Acetone · in 1 record
- GSH · Glutathione · in 1 record
- JR7 · N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]propanamide · in 1 record
- JRD · N-[(3-methyl-1,2-oxazol-5-yl)methyl]-N-(4-phenyl-1,3-thiazol-2-yl)propanamide · in 1 record
- XX0 · 2-chloro-N-{4-chloro-3-[(morpholin-4-yl) sulfonyl]phenyl}acetamide · in 1 record
Elsewhere
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