MolNFT v1 · #160076 · protein
Crystal structure of hmat mutant K289L
6P9V · S-adenosylmethionine synthase isoform type-2: “Crystal structure of hmat mutant K289L”. X-ray diffraction, 4 ligands (ADN, POP, K), 2 pockets (best druggability 0.38). MolNFT v1 #160076 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6P9V
- Type
- protein
- Length
- 380 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-adenosylmethionine synthase isoform type-2
- EC
- 2.5.1.6
- UniProt
- P31153
- Ligands
- ADN, POP, K, MG
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-adenosylmethionine synthase isoform type-2 (EC 2.5.1.6) | protein | 380 | 34% helix, 26% strand | P31153 |
Ligands and binding sites
- ADN · Adenosine · ligand · chains A
- POP · Pyrophosphate 2- · ligand · chains A
- K · Potassium ion · metal · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.38 | 0.77 | 19 | empty |
| 2 | 57 | 0.33 | 0.77 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31153
- Elsewhere: RCSB PDB 6P9V · PDBe 6P9V · UniProt P31153
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