MolNFT v1 · #159214 · protein

Crystal structure of human WDR5 in complex with symmetric dimethyl-L- arginine

6OI2 · Wd repeat-containing protein 5: “Crystal structure of human WDR5 in complex with symmetric dimethyl-L- arginine”. X-ray diffraction, 2 ligands (2MR, SO4), 1 pocket (best druggability 0.76). MolNFT v1 #159214 on GenesisL1: 3D…

PDB: 6OI2
Type: protein
Length: 304 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wd repeat-containing protein 5
UniProt: P61964
Ligands: 2MR, SO4
Pockets: 1 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wd repeat-containing protein 5	protein	304	0% helix, 51% strand	P61964

Ligands and binding sites

2MR · N3, N4-dimethylarginine · ligand · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	668	0.76	0.82	65	SO4, 2MR

Compared structures

6OI2 · Crystal structure of human WDR5 in complex with symmetric dimethyl-L-arginine · the same entry in another collection · chain A against A, TM-score 1.00
P61964 · AlphaFold monomer V2.0 prediction for wd repeat-containing protein 5 (P61964) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61964
Elsewhere: RCSB PDB 6OI2 · PDBe 6OI2 · UniProt P61964

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