MolNFT v1 · #157947 · protein
Structure of beta-klotho in complex with FGF19 C-terminal peptide
6NFJ: “Structure of beta-klotho in complex with FGF19 C-terminal peptide”. X-ray diffraction, 20 pockets (best druggability 0.74). MolNFT v1 #157947 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NFJ
- Type
- protein
- Length
- 1,952 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-klotho; Nanobody 30; Fibroblast growth factor 19
- UniProt
- Q86Z14, O95750
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 5 distinct chains · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-klotho | protein | 844 | 43% helix, 17% strand | Q86Z14 |
| B | Nanobody 30 | protein | 111 | 3% helix, 42% strand | — |
| C, F | Fibroblast growth factor 19 | protein | 19 | 0% helix, 5% strand | O95750 |
| D | Beta-klotho | protein | 846 | 42% helix, 15% strand | Q86Z14 |
| E | Nanobody 30 | protein | 113 | 8% helix, 42% strand | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 933 | 0.74 | 0.78 | 90 | empty |
| 2 | 52 | 0.73 | 0.99 | 19 | empty |
| 3 | 58 | 0.71 | 0.98 | 25 | empty |
| 4 | 57 | 0.71 | 0.98 | 28 | empty |
| 5 | 537 | 0.69 | 0.79 | 73 | empty |
Interfaces
6 interfaces between chains.
- D–E · 990 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 973 Ų buried · 11 hydrogen bonds · protein-protein
- D–F · 935 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 905 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 485 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6NFJ · Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide · the same entry in another collection · chain F against F, TM-score 1.00
- Q86Z14 · AlphaFold monomer V2.0 prediction for beta-klotho (Q86Z14) · a predicted model of the same protein · chain D against A, TM-score 0.95
- O95750 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 19 (O95750) · a predicted model of the same protein · chain F against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86Z14
- Every structure of UniProt O95750
- Elsewhere: RCSB PDB 6NFJ · PDBe 6NFJ · UniProt Q86Z14 · UniProt O95750
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