UniProt Q86Z14
Beta-klotho (Q86Z14)
Beta-klotho (UniProt Q86Z14): 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q86Z14
- Protein
- Beta-klotho
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 31 · 3 records with a druggable one
Structures
11 records of Q86Z14 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5VAK | Crystal Structure of Beta-Klotho, Domain 1 | x-ray diffraction | A | NAG | 4 (best 0.47) |
| 5VAK | Crystal structure of beta-klotho, domain 1 | x-ray diffraction | A | NAG | — |
| 5VAN | Crystal Structure of Beta-Klotho | x-ray diffraction | A | NAG, BGC | 6 (best 0.70) |
| 5VAN | Crystal structure of beta-klotho | x-ray diffraction | A | NAG, BGC | — |
| 5VAQ | Crystal Structure of Beta-Klotho in Complex with FGF21CT | x-ray diffraction | A | NAG | 9 (best 0.71) |
| 5VAQ | Crystal structure of beta-klotho in complex with FGF21CT | x-ray diffraction | A | NAG | — |
| 5WI9 | Crystal structure of KL with an agonist Fab | x-ray diffraction | A, B | NAG, SO4 | 12 (best 0.83) |
| 5WI9 | Crystal structure of kl with an agonist Fab | x-ray diffraction | A, B | NAG, SO4 | — |
| 6NFJ | Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide | x-ray diffraction | A, D | — | — |
| 6NFJ | Structure of beta-klotho in complex with FGF19 C-terminal peptide | x-ray diffraction | A, D | — | — |
| Q86Z14 | AlphaFold monomer V2.0 prediction for beta-klotho (Q86Z14) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5WI9 chain B against the predicted model Q86Z14: TM-score 1.00, RMSD 0.30 Å
- 5WI9 chain A against the predicted model Q86Z14: TM-score 1.00, RMSD 0.31 Å
- 5WI9 chain A against the predicted model Q86Z14: TM-score 1.00, RMSD 0.31 Å
- 5VAK chain A against the predicted model Q86Z14: TM-score 1.00, RMSD 0.43 Å
- 5VAK chain A against the predicted model Q86Z14: TM-score 1.00, RMSD 0.43 Å
- 5VAN chain A against the predicted model Q86Z14: TM-score 1.00, RMSD 0.59 Å
- 5VAN chain A against the predicted model Q86Z14: TM-score 1.00, RMSD 0.59 Å
- 5VAQ chain A against the predicted model Q86Z14: TM-score 0.99, RMSD 0.82 Å
- 5VAQ chain A against the predicted model Q86Z14: TM-score 0.99, RMSD 0.82 Å
- 6NFJ chain D against the predicted model Q86Z14: TM-score 0.95, RMSD 2.40 Å
Elsewhere
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