MolNFT v1 · #157724 · protein
Cryo-EM structure of the IMPORTIN7:IMPORTIN BETA:HISTONE H1.0 complex
6N88 · MGC52556 protein: “Cryo-EM structure of the IMPORTIN7:IMPORTIN BETA:HISTONE H1.0 complex”. Electron microscopy, 7 pockets (best druggability 0.57). MolNFT v1 #157724 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6N88
- Type
- protein
- Length
- 1,566 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MGC52556 protein; Importin subunit beta-1; Histone H1.0
- UniProt
- O42480, Q14974, P07305
- Pockets
- 7 · best druggability 0.57
Structure
electron microscopy · 3 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MGC52556 protein | protein | 619 | 74% helix, 0% strand | O42480 |
| B | Importin subunit beta-1 | protein | 873 | 68% helix, 0% strand | Q14974 |
| C | Histone H1.0 | protein | 74 | 49% helix, 18% strand | P07305 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 445 | 0.57 | 0.74 | 55 | empty |
| 2 | 298 | 0.48 | 0.73 | 60 | empty |
| 3 | 128 | 0.34 | 0.72 | 33 | empty |
| 4 | 116 | 0.33 | 0.72 | 26 | empty |
| 5 | 92 | 0.29 | 0.72 | 27 | empty |
Interfaces
2 interfaces between chains.
- A–B · 74 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 53 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6N88 · Cryo-EM structure of the Importin7:Importin beta:Histone H1.0 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P07305 · AlphaFold monomer V2.0 prediction for histone H1.0 (P07305) · a predicted model of the same protein · chain C against A, TM-score 0.84
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain B against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O42480
- Every structure of UniProt Q14974
- Every structure of UniProt P07305
- Elsewhere: RCSB PDB 6N88 · PDBe 6N88 · UniProt O42480 · UniProt Q14974 · UniProt P07305
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