MolNFT v1 · #157546 · protein

Wd repeats of human WDR12

6N31 · Ribosome biogenesis protein WDR12: “Wd repeats of human WDR12”. X-ray diffraction, 1 ligand (UNX), 3 pockets (best druggability 0.76). MolNFT v1 #157546 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6N31
Type: protein
Length: 620 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosome biogenesis protein WDR12
UniProt: Q9GZL7
Ligands: UNX
Pockets: 3 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribosome biogenesis protein WDR12	protein	308	0% helix, 54% strand	Q9GZL7
B	Ribosome biogenesis protein WDR12	protein	312	0% helix, 54% strand	Q9GZL7

Ligands and binding sites

UNX · Unknown atom or ion · ion · 36 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	885	0.76	0.79	73	UNX
2	778	0.76	0.80	62	UNX
3	56	0.25	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 515 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6N31 · WD repeats of human WDR12 · the same entry in another collection · chain A against A, TM-score 1.00
Q9GZL7 · AlphaFold monomer V2.0 prediction for ribosome biogenesis protein WDR12 (Q9GZL7) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZL7
Elsewhere: RCSB PDB 6N31 · PDBe 6N31 · UniProt Q9GZL7

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