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MolNFT v1 · #156884 · protein

Structure of NEMO(51-112) with N- and C-terminal coiled-coil adaptors.

6MI3 · Nf-kb essential MODULATOR,NF-kappa-B essential modulator…: “Structure of NEMO(51-112) with N- and C-terminal coiled-coil adaptors.”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #156884 on GenesisL1: 3D structure…

PDB
6MI3
Type
protein
Length
246 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Nf-kb essential MODULATOR,NF-kappa-B essential modulator, nf-kb essential modulator
UniProt
Q9Y6K9
Pockets
1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 95% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ANf-kb essential MODULATOR,NF-kappa-B essential modulator, nf-kb essential modulatorprotein12296% helix, 0% strandQ9Y6K9
BNf-kb essential MODULATOR,NF-kappa-B essential modulator, nf-kb essential modulatorprotein12494% helix, 0% strandQ9Y6K9

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1680.310.7413empty

Interfaces

1 interface between chains.

  • A–B · 3120 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

  • 6MI3 · Structure of NEMO(51-112) with N- and C-terminal coiled-coil adaptors. · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9Y6K9 · AlphaFold monomer V2.0 prediction for nf-kappa-B essential modulator (Q9Y6K9) · a predicted model of the same protein · chain B against A, TM-score 0.88

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