MolNFT v1 · #156833 · protein

Structure of rabbit actin in complex with mycalolide B

6MGO · Actin, alpha skeletal muscle: “Structure of rabbit actin in complex with mycalolide B”. X-ray diffraction, 3 ligands (JQV, ADP, CA), 2 pockets (best druggability 0.72). MolNFT v1 #156833 on GenesisL1: 3D structure, binding sites and…

PDB: 6MGO
Type: protein
Length: 359 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin, alpha skeletal muscle
UniProt: P68135
Ligands: JQV, ADP, CA
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin, alpha skeletal muscle	protein	359	44% helix, 19% strand	P68135

Ligands and binding sites

JQV · Mycalolide B · ligand · chains A
ADP · Adenosine-5'-diphosphate · ligand · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	374	0.72	0.84	54	CA, ADP
2	128	0.43	0.75	24	empty

Compared structures

6MGO · Structure of rabbit actin in complex with Mycalolide B · the same entry in another collection · chain A against A, TM-score 1.00
P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68135
Elsewhere: RCSB PDB 6MGO · PDBe 6MGO · UniProt P68135

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