X-ray structure of a drosophila dopamine transporter with subsiteb mutations (D121G/S426M) in S-duloxetine bound form

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• 29E · (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl) propan-1-amine · ligand · chains A
• Y01 · Cholesterol hemisuccinate · ligand · chains A
• CLR · Cholesterol · ligand · chains A
• NA · Sodium ion · metal · 2 copies · chains A
• CL · Chloride ion · ion · chains A
• DMU · Decyl-beta-D-maltopyranoside · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6M38 · X-ray structure of a Drosophila dopamine transporter with subsiteB mutations… · the same entry in another collection · chain A against A, TM-score 1.00
• Q7K4Y6 · AlphaFold monomer V2.0 prediction for sodium-dependent dopamine transporter (Q7K4Y6) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q7K4Y6
• Elsewhere: RCSB PDB 6M38 · PDBe 6M38 · UniProt Q7K4Y6