Crystal structure of GPR52 in complex with agonist C17

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• EN6 · N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide · ligand · chains A
• FMN · Flavin mononucleotide · ligand · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 17 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 8 copies · chains A
• FLC · Citrate anion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6LI0 · Crystal structure of GPR52 in complex with agonist c17 · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y2T5 · AlphaFold monomer V2.0 prediction for G-protein coupled receptor 52 (Q9Y2T5) · a predicted model of the same protein · chain A against A, TM-score 0.65
• P00323 · AlphaFold monomer V2.0 prediction for flavodoxin (P00323) · a predicted model of the same protein · chain A against A, TM-score 0.33

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y2T5
• Every structure of UniProt P00323
• Elsewhere: RCSB PDB 6LI0 · PDBe 6LI0 · UniProt Q9Y2T5 · UniProt P00323