MolNFT v1 · #155145 · protein

Crystal structure of ATG18 from saccharomyces cerevisiae

6KYB · Autophagy-related protein 18: “Crystal structure of ATG18 from saccharomyces cerevisiae”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #155145 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6KYB
Type: protein
Length: 1,304 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Autophagy-related protein 18
UniProt: P43601
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 4 distinct chains · 0% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Autophagy-related protein 18	protein	329	0% helix, 52% strand	P43601
B	Autophagy-related protein 18	protein	330	0% helix, 55% strand	P43601
C	Autophagy-related protein 18	protein	328	0% helix, 51% strand	P43601
D	Autophagy-related protein 18	protein	317	0% helix, 38% strand	P43601

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.80	0.97	34	empty
2	695	0.80	0.84	57	empty
3	690	0.80	0.84	55	empty
4	1064	0.80	0.81	89	empty
5	735	0.79	0.83	58	empty

Interfaces

2 interfaces between chains.

B–C · 822 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 814 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

6KYB · Crystal structure of Atg18 from Saccharomyces cerevisiae · the same entry in another collection · chain D against D, TM-score 1.00
P43601 · AlphaFold monomer V2.0 prediction for autophagy-related protein 18 (P43601) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43601
Elsewhere: RCSB PDB 6KYB · PDBe 6KYB · UniProt P43601

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