MolNFT v1 · #154902 · protein
Crystal structure of E136F mutant of xanthine-guanine phosphoribosyltransferase from yersinia pestis
6KQC · Xanthine phosphoribosyltransferase: “Crystal structure of E136F mutant of xanthine-guanine phosphoribosyltransferase from yersinia pestis”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.50). MolNFT v1 #154902 on…
- PDB
- 6KQC
- Type
- protein
- Length
- 283 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Xanthine phosphoribosyltransferase
- EC
- 2.4.2.22
- UniProt
- Q8ZC05
- Ligands
- CL
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Xanthine phosphoribosyltransferase (EC 2.4.2.22) | protein | 142 | 30% helix, 29% strand | Q8ZC05 |
| B | Xanthine phosphoribosyltransferase (EC 2.4.2.22) | protein | 141 | 30% helix, 29% strand | Q8ZC05 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.50 | 0.76 | 24 | CL |
| 2 | 143 | 0.43 | 0.75 | 20 | CL |
Interfaces
1 interface between chains.
- A–B · 1475 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 6KQC · Crystal structure of E136F mutant of Xanthine-guanine phosphoribosyltransferase from… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8ZC05 · AlphaFold monomer V2.0 prediction for xanthine-guanine phosphoribosyltransferase (Q8ZC05) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ZC05
- Elsewhere: RCSB PDB 6KQC · PDBe 6KQC · UniProt Q8ZC05
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