MolNFT v1 · #15489 · protein

Structure of SET7/9

1N6A · Set domain-containing protein 7: “Structure of SET7/9”. X-ray diffraction, 1 ligand (SAM), 1 pocket (best druggability 0.44). MolNFT v1 #15489 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1N6A
Type: protein
Length: 234 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Set domain-containing protein 7
UniProt: Q8WTS6
Ligands: SAM
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Set domain-containing protein 7	protein	234	13% helix, 40% strand	Q8WTS6

Ligands and binding sites

SAM · S-adenosylmethionine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.44	0.76	26	SAM

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

1N6A · Structure of SET7/9 · the same entry in another collection · chain A against A, TM-score 1.00
Q8WTS6 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD7 (Q8WTS6) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WTS6
Elsewhere: RCSB PDB 1N6A · PDBe 1N6A · UniProt Q8WTS6

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