MolNFT v1 · #154767 · protein
Crystal structure of human WIPI3 in complex with the wir-peptide from ATG2A
6KLR · Chimera ATG2A and WIPI3: “Crystal structure of human WIPI3 in complex with the wir-peptide from ATG2A”. X-ray diffraction, 4 pockets (best druggability 0.77). MolNFT v1 #154767 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6KLR
- Type
- protein
- Length
- 319 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chimera ATG2A and WIPI3
- UniProt
- Q2TAZ0, Q5MNZ6
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chimera ATG2A and WIPI3 | protein | 297 | 0% helix, 52% strand | Q2TAZ0, Q5MNZ6 |
| B | Chimera ATG2A and WIPI3 | protein | 22 | 0% helix, 18% strand | Q2TAZ0, Q5MNZ6 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 514 | 0.77 | 0.84 | 48 | empty |
| 2 | 56 | 0.60 | 0.91 | 20 | empty |
| 3 | 61 | 0.34 | 0.77 | 16 | empty |
| 4 | 64 | 0.32 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1298 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 6KLR · Crystal structure of human WIPI3 in complex with the WIR-peptide from ATG2A · the same entry in another collection · chain A against A, TM-score 1.00
- Q5MNZ6 · AlphaFold monomer V2.0 prediction for wd repeat domain phosphoinositide-interacting… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q2TAZ0 · AlphaFold monomer V2.0 prediction for autophagy-related protein 2 homolog a (Q2TAZ0) · a predicted model of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2TAZ0
- Every structure of UniProt Q5MNZ6
- Elsewhere: RCSB PDB 6KLR · PDBe 6KLR · UniProt Q2TAZ0 · UniProt Q5MNZ6
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