MolNFT v1 · #499889 · protein
AlphaFold monomer V2.0 prediction for wd repeat domain phosphoinositide-interacting protein 3 (Q5MNZ6)
Q5MNZ6: “AlphaFold monomer V2.0 prediction for wd repeat domain phosphoinositide-interacting protein 3 (Q5MNZ6)”. 4 pockets (best druggability 0.81). MolNFT v1 #499889 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q5MNZ6
- Type
- protein
- Length
- 344 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x80D2ac0F5e3268bC5C1d28BBAA07E3169BB02b79
- Molecule
- Wd repeat domain phosphoinositide-interacting protein 3
- UniProt
- Q5MNZ6
- Pockets
- 4 · best druggability 0.81
Structure
1 distinct chain · 2% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat domain phosphoinositide-interacting protein 3 | protein | 344 | 2% helix, 49% strand | Q5MNZ6 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 464 | 0.81 | 0.88 | 42 | empty |
| 2 | 74 | 0.37 | 0.78 | 18 | empty |
| 3 | 64 | 0.36 | 0.78 | 14 | empty |
| 4 | 55 | 0.34 | 0.78 | 18 | empty |
Compared structures
- 8ZQG · Crystal structure of WIPI3 in complex with ATG16L1 · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 6IYY · Crystal structure of human WIPI3,loop deletion mutant · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 6IYY · Crystal structure of human WIPI3,LOOP deletion mutant · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 9C9I · Structure of the TSC1:WIPI3 complex · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 9CE3 · Structure of the TSC:WIPI3 lysosomal recruitment complex · an experimental structure of the same protein · chain A against F, TM-score 0.87
- 6KLR · Crystal structure of human WIPI3 in complex with the wir-peptide from ATG2A · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 6KLR · Crystal structure of human WIPI3 in complex with the WIR-peptide from ATG2A · an experimental structure of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5MNZ6
- Elsewhere: UniProt Q5MNZ6 · AlphaFold DB Q5MNZ6
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