MolNFT v1 · #154717 · protein

Structure of thermal-STABILISED(M6) human glp-1 receptor transmembrane domain

6KK7 · Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like…: “Structure of thermal-STABILISED(M6) human glp-1 receptor transmembrane domain”. X-ray diffraction, 1 ligand (97Y), 17 pockets (best druggability 0.68). MolNFT v1 #154717 on…

PDB: 6KK7
Type: protein
Length: 844 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like peptide 1 receptor
UniProt: P43220, P00720
Ligands: 97Y
Pockets: 17 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like peptide 1 receptor	protein	423	74% helix, 3% strand	P43220, P00720
B	Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like peptide 1 receptor	protein	421	74% helix, 3% strand	P43220, P00720

Ligands and binding sites

97Y · N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	646	0.68	0.76	56	empty
2	612	0.67	0.76	53	empty
3	223	0.62	0.82	27	empty
4	219	0.60	0.81	33	empty
5	196	0.57	0.80	33	empty

Interfaces

1 interface between chains.

A–B · 471 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6KK7 · Structure of thermal-stabilised(M6) human GLP-1 receptor transmembrane domain · the same entry in another collection · chain A against A, TM-score 1.00
P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain A against A, TM-score 0.56

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43220
Every structure of UniProt P00720
Elsewhere: RCSB PDB 6KK7 · PDBe 6KK7 · UniProt P43220 · UniProt P00720

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