MolNFT v1 · #154711 · protein

Structure of thermal-STABILISED(M8) human glp-1 receptor transmembrane domain

6KK1 · Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like…: “Structure of thermal-STABILISED(M8) human glp-1 receptor transmembrane domain”. X-ray diffraction, 1 ligand (97Y), 12 pockets (best druggability 0.69). MolNFT v1 #154711 on…

PDB: 6KK1
Type: protein
Length: 847 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like peptide 1 receptor
UniProt: P43220, P00720
Ligands: 97Y
Pockets: 12 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like peptide 1 receptor	protein	423	74% helix, 3% strand	P43220, P00720
B	Glucagon-like peptide 1 RECEPTOR,ENDOLYSIN,GLUCAGON-like peptide 1 receptor	protein	424	74% helix, 3% strand	P43220, P00720

Ligands and binding sites

97Y · N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	660	0.69	0.77	53	empty
2	443	0.69	0.80	53	empty
3	607	0.66	0.76	46	empty
4	230	0.60	0.80	26	empty
5	211	0.59	0.81	28	empty

Interfaces

1 interface between chains.

A–B · 565 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6KK1 · Structure of thermal-stabilised(M8) human GLP-1 receptor transmembrane domain · the same entry in another collection · chain A against A, TM-score 1.00
P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain B against A, TM-score 0.56

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43220
Every structure of UniProt P00720
Elsewhere: RCSB PDB 6KK1 · PDBe 6KK1 · UniProt P43220 · UniProt P00720

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