MolNFT v1 · #154528 · protein
Crystal structure of TTCAS1
6KE1 · CRISPR-associated endonuclease CAS1 2: “Crystal structure of TTCAS1”. X-ray diffraction, 8 pockets (best druggability 0.82). MolNFT v1 #154528 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6KE1
- Type
- protein
- Length
- 515 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR-associated endonuclease CAS1 2
- EC
- 3.1.-.-
- UniProt
- Q53WG8
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CRISPR-associated endonuclease CAS1 2 (EC 3.1.-.-) | protein | 260 | 48% helix, 13% strand | Q53WG8 |
| B | CRISPR-associated endonuclease CAS1 2 (EC 3.1.-.-) | protein | 255 | 51% helix, 15% strand | Q53WG8 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.82 | 0.97 | 26 | empty |
| 2 | 88 | 0.66 | 0.91 | 17 | empty |
| 3 | 279 | 0.51 | 0.74 | 43 | empty |
| 4 | 62 | 0.42 | 0.82 | 16 | empty |
| 5 | 74 | 0.42 | 0.79 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1958 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q53WG8
- Elsewhere: RCSB PDB 6KE1 · PDBe 6KE1 · UniProt Q53WG8
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