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Crystal structure of TTCAS1

Analyse Crystal structure of TTCAS1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KE1
Type: protein
Length: 515 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRISPR-associated endonuclease CAS1 2
EC: 3.1.-.-
UniProt: Q53WG8
Pockets: 8 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CRISPR-associated endonuclease CAS1 2 (EC 3.1.-.-)	protein	260	48% helix, 13% strand	Q53WG8
B	CRISPR-associated endonuclease CAS1 2 (EC 3.1.-.-)	protein	255	51% helix, 15% strand	Q53WG8

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	167	0.82	0.97	26	empty
2	88	0.66	0.91	17	empty
3	279	0.51	0.74	43	empty
4	62	0.42	0.82	16	empty
5	74	0.42	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 1958 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

6KE1 · Crystal structure of TtCas1 · the same entry in another collection · chain A against A, TM-score 1.00
Q53WG8 · AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS1 2 (Q53WG8) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53WG8
Elsewhere: RCSB PDB 6KE1 · PDBe 6KE1 · UniProt Q53WG8

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