UniProt Q53WG8

CRISPR-associated endonuclease Cas1 2 (Q53WG8)

CRISPR-associated endonuclease Cas1 2 (UniProt Q53WG8), EC 3.1.-.-: 4 experimental structures and 1 predicted model on GenesisL1, 61 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q53WG8
Protein: CRISPR-associated endonuclease Cas1 2
EC: 3.1.-.-
Experimental structures: 4
Predicted models: 1
Pockets: 61 · 5 records with a druggable one

Structures

5 records of Q53WG8 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6KDV	Crystal structure of TtCas1-DNA complex	x-ray diffraction	B, A, D, C	—	20 (best 0.85)
6KDV	Crystal structure of TTCAS1-DNA complex	x-ray diffraction	B, A, D, C	—	20 (best 0.85)
6KE1	Crystal structure of TtCas1	x-ray diffraction	A, B	—	8 (best 0.82)
6KE1	Crystal structure of TTCAS1	x-ray diffraction	A, B	—	8 (best 0.82)
Q53WG8	AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS1 2 (Q53WG8)	predicted	A	—	5 (best 0.50)

Experiment against prediction

6KDV chain A against the predicted model Q53WG8: TM-score 0.98, RMSD 0.88 Å
6KDV chain A against the predicted model Q53WG8: TM-score 0.98, RMSD 0.88 Å
6KDV chain C against the predicted model Q53WG8: TM-score 0.98, RMSD 0.92 Å
6KDV chain C against the predicted model Q53WG8: TM-score 0.98, RMSD 0.92 Å
6KE1 chain B against the predicted model Q53WG8: TM-score 0.97, RMSD 1.14 Å
6KE1 chain B against the predicted model Q53WG8: TM-score 0.97, RMSD 1.14 Å
6KDV chain B against the predicted model Q53WG8: TM-score 0.80, RMSD 3.31 Å
6KDV chain B against the predicted model Q53WG8: TM-score 0.80, RMSD 3.31 Å
6KDV chain D against the predicted model Q53WG8: TM-score 0.80, RMSD 3.22 Å
6KDV chain D against the predicted model Q53WG8: TM-score 0.80, RMSD 3.22 Å

Elsewhere

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