MolNFT v1 · #15442 · protein

Atomic resolution structure of cholesterol oxidase @pH 5.8 (streptomyces sp. sa-coo)

1N4V: “Atomic resolution structure of cholesterol oxidase @pH 5.8 (streptomyces sp. sa-coo)”. X-ray diffraction, 1 ligand (FAD), 3 pockets (best druggability 0.86). MolNFT v1 #15442 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1N4V
Type: protein
Length: 498 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cholesterol oxidase
EC: 1.1.3.6
UniProt: P12676
Ligands: FAD
Pockets: 3 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cholesterol oxidase (EC 1.1.3.6)	protein	498	29% helix, 24% strand	P12676

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	726	0.86	0.89	85	FAD
2	173	0.57	0.81	32	empty
3	91	0.33	0.74	24	empty

Compared structures

1N4V · ATOMIC RESOLUTION STRUCTURE OF CHOLESTEROL OXIDASE @pH 5.8 (STREPTOMYCES SP. SA-COO) · the same entry in another collection · chain A against A, TM-score 1.00
P12676 · AlphaFold monomer V2.0 prediction for cholesterol oxidase (P12676) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12676
Elsewhere: RCSB PDB 1N4V · PDBe 1N4V · UniProt P12676

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