MolNFT v1 · #154126 · protein
Structure of N6AMT1-TRMT112 complex with SAM
6K0X · Methyltransferase N6AMT1: “Structure of N6AMT1-TRMT112 complex with SAM”. X-ray diffraction, 1 ligand (SAM), 3 pockets (best druggability 0.75). MolNFT v1 #154126 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6K0X
- Type
- protein
- Length
- 318 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methyltransferase N6AMT1; Multifunctional methyltransferase subunit TRM112-like protein
- EC
- 2.1.1.-, 2.1.1.72
- UniProt
- Q9Y5N5, Q9UI30
- Ligands
- SAM
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methyltransferase N6AMT1 (EC 2.1.1.-, 2.1.1.72) | protein | 195 | 38% helix, 28% strand | Q9Y5N5 |
| B | Multifunctional methyltransferase subunit TRM112-like protein | protein | 123 | 34% helix, 21% strand | Q9UI30 |
Ligands and binding sites
- SAM · S-adenosylmethionine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.75 | 0.91 | 44 | SAM |
| 2 | 105 | 0.62 | 0.87 | 22 | empty |
| 3 | 166 | 0.49 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1204 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6K0X · Structure of N6AMT1-TRMT112 Complex with SAM · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y5N5 · AlphaFold monomer V2.0 prediction for methyltransferase N6AMT1 (Q9Y5N5) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9UI30 · AlphaFold monomer V2.0 prediction for multifunctional methyltransferase subunit… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y5N5
- Every structure of UniProt Q9UI30
- Elsewhere: RCSB PDB 6K0X · PDBe 6K0X · UniProt Q9Y5N5 · UniProt Q9UI30
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.