UniProt Q9UI30
Multifunctional methyltransferase subunit TRM112-like protein (Q9UI30)
Multifunctional methyltransferase subunit TRM112-like protein (UniProt Q9UI30): 22 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9UI30
- Protein
- Multifunctional methyltransferase subunit TRM112-like protein
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 4 records with a druggable one
Structures
23 records of Q9UI30 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G4W | Cryo-EM structure of a late human pre-40S ribosomal subunit - State A | electron microscopy | r | — | 1 (best 0.84) |
| 6G4W | Cryo-EM structure of a late human pre-40S ribosomal subunit - state a | electron microscopy | r | — | — |
| 6H1D | Crystal structure of C21orf127-TRMT112 in complex with SAH | x-ray diffraction | B | — | — |
| 6H1D | Crystal structure of C21ORF127-TRMT112 in complex with sah | x-ray diffraction | B | — | — |
| 6H1E | Crystal structure of C21ORF127-TRMT112 in complex with sah and H4 peptide | x-ray diffraction | B | — | — |
| 6H2U | Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 1.6A… | x-ray diffraction | B | — | — |
| 6H2U | Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA M6A1832 methyltransferase at 1.6A… | x-ray diffraction | B | — | — |
| 6H2V | Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 2.5A… | x-ray diffraction | B, D | SO4 | — |
| 6H2V | Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA M6A1832 methyltransferase at 2.5A… | x-ray diffraction | B, D | SO4 | — |
| 6K0X | Structure of N6AMT1-TRMT112 complex with SAM | x-ray diffraction | B | — | — |
| 6KHS | Crystal structure of HEMK2/TRMT112 in complex with sah and meq | x-ray diffraction | B | — | — |
| 6KMR | Crystal structure of human N6amt1-Trm112 in complex with SAM (space group P6122) | x-ray diffraction | A | — | — |
| 6KMR | Crystal structure of human N6AMT1-TRM112 in complex with SAM (space group P6122) | x-ray diffraction | A | — | — |
| 6KMS | Crystal structure of human N6amt1-Trm112 in complex with SAM (space group I422) | x-ray diffraction | A, B | — | — |
| 6KMS | Crystal structure of human N6AMT1-TRM112 in complex with SAM (space group I422) | x-ray diffraction | A, B | — | — |
| 6PED | Crystal structure of HEMK2-TRMT112 complex | x-ray diffraction | B | UNX | — |
| 7WTS | Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14 | electron microscopy | r | — | — |
| 7WTT | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (with CK1) | electron microscopy | r | — | — |
| 7WTW | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3 | electron microscopy | r | — | — |
| 8CNC | Structure of compound 1 bound KMT9 | x-ray diffraction | B | — | 2 (best 0.59) |
| 8QDG | compound 1a bound KMT9 crystal structure | x-ray diffraction | B | — | 2 (best 0.60) |
| 8QDI | compound 1b bound KMT9 crystal structure | x-ray diffraction | B | — | 2 (best 0.58) |
| Q9UI30 | AlphaFold monomer V2.0 prediction for multifunctional methyltransferase subunit TRM112-like protein… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8CNC chain B against the predicted model Q9UI30: TM-score 0.98, RMSD 0.54 Å
- 8QDI chain B against the predicted model Q9UI30: TM-score 0.98, RMSD 0.54 Å
- 8QDG chain B against the predicted model Q9UI30: TM-score 0.98, RMSD 0.59 Å
- 6H1E chain B against the predicted model Q9UI30: TM-score 0.98, RMSD 0.64 Å
- 6H1D chain B against the predicted model Q9UI30: TM-score 0.97, RMSD 0.66 Å
- 6H1D chain B against the predicted model Q9UI30: TM-score 0.97, RMSD 0.66 Å
- 6KHS chain B against the predicted model Q9UI30: TM-score 0.97, RMSD 0.74 Å
- 6K0X chain B against the predicted model Q9UI30: TM-score 0.97, RMSD 0.75 Å
- 6KMR chain A against the predicted model Q9UI30: TM-score 0.96, RMSD 0.91 Å
- 6KMR chain A against the predicted model Q9UI30: TM-score 0.96, RMSD 0.91 Å
Elsewhere
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