MolNFT v1 · #154101 · protein
Crystal structure of REV7(R124A) in complex with a SHIELDIN3 fragment
6K07 · Mitotic spindle assembly checkpoint protein MAD2B: “Crystal structure of REV7(R124A) in complex with a SHIELDIN3 fragment”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.26). MolNFT v1 #154101 on GenesisL1: 3D…
- PDB
- 6K07
- Type
- protein
- Length
- 224 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2B; Shieldin complex subunit 3
- UniProt
- Q9UI95, Q6ZNX1
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.26
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2B | protein | 199 | 35% helix, 30% strand | Q9UI95 |
| B | Shieldin complex subunit 3 | protein | 25 | 40% helix, 12% strand | Q6ZNX1 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.26 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1172 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6K07 · Crystal structure of REV7(R124A) in complex with a Shieldin3 fragment · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q6ZNX1 · AlphaFold monomer V2.0 prediction for shieldin complex subunit 3 (Q6ZNX1) · a predicted model of the same protein · chain B against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UI95
- Every structure of UniProt Q6ZNX1
- Elsewhere: RCSB PDB 6K07 · PDBe 6K07 · UniProt Q9UI95 · UniProt Q6ZNX1
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