MolNFT v1 · #153996 · protein

Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613S triple mutant with sdx-dhp

6JWZ: “Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613S triple mutant with sdx-dhp”. X-ray diffraction, 5 ligands (CKL, AMP, MG). MolNFT v1 #153996 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JWZ
Type: protein
Length: 1,115 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q25704
Ligands: CKL, AMP, MG, CA, PO4

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	550	—	Q25704
B	—	protein	565	—	Q25704

Ligands and binding sites

CKL · 4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide · ligand · 2 copies · chains A, B
AMP · Adenosine monophosphate · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B
CA · Calcium ion · metal · 2 copies · chains A, B
PO4 · Phosphate ion · ion · 2 copies · chains A, B
ACT · Acetate ion · additive · 2 copies · chains A, B
PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6JWZ · Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S triple mutant with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q25704
Elsewhere: RCSB PDB 6JWZ · PDBe 6JWZ · UniProt Q25704

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