UniProt Q25704
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase (Q25704)
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase (UniProt Q25704): 21 experimental structures on GenesisL1, 12 ligands bound, 99 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q25704
- Protein
- 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 99 · 5 records with a druggable one
Structures
21 records of Q25704 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6JWQ | Crystal structure of plasmodium falciparum hppk-dhps wild type | x-ray diffraction | A, B | MG, ATP, CA, AMP | — |
| 6JWR | Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with Pteroate | x-ray diffraction | A, B | PT1, AMP, MG, PH2, CA | 20 (best 0.65) |
| 6JWR | Crystal structure of plasmodium falciparum hppk-dhps wild type with pteroate | x-ray diffraction | A, B | PT1, AMP, MG, PH2, CA | — |
| 6JWS | Crystal structure of plasmodium falciparum hppk-dhps A437G with pteroate | x-ray diffraction | A, B | PT1, ATP, MG, CA | — |
| 6JWT | Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate | x-ray diffraction | A, B | AMP, MG, PT1, CA, ATP | — |
| 6JWT | Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613T triple mutant with pteroate | x-ray diffraction | A, B | AMP, MG, PT1, CA, ATP | — |
| 6JWU | Crystal structure of plasmodium falciparum hppk-dhps wild type with stz-dhp | x-ray diffraction | A, B | XTZ, PH2, PO4, AMP, MG, CA | — |
| 6JWV | Crystal structure of plasmodium falciparum hppk-dhps A437G with stz- dhp | x-ray diffraction | A, B | XTZ, PH2, ATP, MG, CA | — |
| 6JWW | Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP | x-ray diffraction | A, B | XTZ, PH2, ATP, MG, CA, AMP | 19 (best 0.66) |
| 6JWW | Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613T triple mutant with stz-dhp | x-ray diffraction | A, B | XTZ, PH2, ATP, MG, CA, AMP | — |
| 6JWX | Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with SDX-DHP | x-ray diffraction | A, B | CKL, PH2, AMP, MG, CA | 20 (best 0.68) |
| 6JWX | Crystal structure of plasmodium falciparum hppk-dhps wild type with sdx-dhp | x-ray diffraction | A, B | CKL, PH2, AMP, MG, CA | — |
| 6JWY | Crystal structure of plasmodium falciparum hppk-dhps A437G with sdx- dhp | x-ray diffraction | A, B | CKL, PH2, ATP, MG, CA | — |
| 6JWZ | Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S triple mutant with SDX-DHP | x-ray diffraction | A, B | CKL, PO4, AMP, MG, CA | 20 (best 0.66) |
| 6JWZ | Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613S triple mutant with sdx-dhp | x-ray diffraction | A, B | CKL, PO4, AMP, MG, CA | — |
| 6KCK | Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with pterin and p-hydroxybenzoate | x-ray diffraction | A, B | PE0, PHB, APC, MG, CA | 20 (best 0.65) |
| 6KCK | Crystal structure of plasmodium falciparum hppk-dhps wild type with pterin and P-hydroxybenzoate | x-ray diffraction | A, B | PE0, PHB, APC, MG, CA | — |
| 6KCL | Crystal structure of Plasmodium falciparum HPPK-DHPS A437G/K540E with pterin and p-hydroxybenzoate | x-ray diffraction | A, B | PE0, PHB, ATP, MG, CA | — |
| 6KCL | Crystal structure of plasmodium falciparum hppk-dhps A437G/K540E with pterin and P-hydroxybenzoate | x-ray diffraction | A, B | PE0, PHB, ATP, MG, CA | — |
| 6KCM | Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S with pterin and… | x-ray diffraction | A, B | PE0, PHB, ATP, MG, CA | — |
| 6KCM | Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613S with pterin and… | x-ray diffraction | A, B | PE0, PHB, ATP, MG, CA | — |
Ligands
- CA · Calcium ion · in 21 records
- MG · Magnesium ion · in 21 records
- AMP · Adenosine monophosphate · in 12 records
- ATP · Adenosine-5'-triphosphate · in 12 records
- PH2 · 2-amino-6-hydroxymethyl-7,8-dihydro-3H-pteridin-4-one · in 9 records
- PE0 · Pterine · in 6 records
- PHB · P-hydroxybenzoic acid · in 6 records
- CKL · 4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide · in 5 records
- PT1 · Pteroic acid · in 5 records
- XTZ · 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl) methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide · in 4 records
- PO4 · Phosphate ion · in 3 records
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 2 records
Elsewhere
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