MolNFT v1 · #153993 · protein

Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613T triple mutant with stz-dhp

6JWW: “Crystal structure of plasmodium falciparum hppk-dhps S436F/A437G/A613T triple mutant with stz-dhp”. X-ray diffraction, 6 ligands (XTZ, PH2, ATP). MolNFT v1 #153993 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JWW
Type: protein
Length: 1,103 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q25704
Ligands: XTZ, PH2, ATP, AMP, MG, CA

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	544	—	Q25704
B	—	protein	559	—	Q25704

Ligands and binding sites

XTZ · 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl) methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide · ligand · 2 copies · chains A, B
PH2 · 2-amino-6-hydroxymethyl-7,8-dihydro-3H-pteridin-4-one · ligand · chains A
ATP · Adenosine-5'-triphosphate · ligand · chains A
AMP · Adenosine monophosphate · ligand · chains B
MG · Magnesium ion · metal · 2 copies · chains A, B
CA · Calcium ion · metal · 2 copies · chains A, B
ACT · Acetate ion · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6JWW · Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q25704
Elsewhere: RCSB PDB 6JWW · PDBe 6JWW · UniProt Q25704

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